Pretargeting Mouse Dosimetry Compared with [177Lu]Lu-DOTA-4AH29
| 4AH29-TCO + [177Lu]Lu-DOTA-PEG7-tetrazine, 8-h lag time | [177Lu]Lu-DOTA-4AH29 | |||
|---|---|---|---|---|
| Organ | cGy/MBq | TI | cGy/MBq | TI |
| Blood | 0.55 | 68 | 0.54 | 110 |
| Kidneys | 15.64 | 2.40 | 134.02 | 0.45 |
| Tumor | 37.54 | — | 60.03 | — |
MADs were calculated using biodistribution data reported in Figure 4.