TABLE 1.

Uncorrected (PET) and PVE-Corrected Counts Derived from StepBrain PET (GM Counts Averaged over GM Regions of Interest)

CompartmentTargetPETRoussetMeltzerMuller- Gartner CSPVEOUTMuller- Gartner RO
GM45.5331.64 ± 1.9845.97 ± 1.4543.30 ± 1.4246.00 ± 1.1646.36 ± 1.1045.98 ± 1.16
WM16.0116.8816.9821.2516.8616.8616.93
Striatum43.7625.8043.5138.3543.7248.2743.67
  • Counts (kBq/mL) measured in GM regions of interest, WM, and striatum compartments are reported both uncorrected (PET) and PVE-corrected using methods proposed by Meltzer, Rousset, Alfano (PVEOUT), and Muller-Gartner with WM activity measured over Centrum Semiovale (Mull-Gart CS) or according to Rousset (Mull-Gart RO), as implemented in PVELab (17), along with true concentrations (Target).