Decline in Spleen Volume from Baseline After 12 Months Enables Discrimination Between Patients with Low and Normal WBC Levels After 24 Months*
| Feature | Cutoff value | Sensitivity | Specificity | ROC-AUC | 95% CI | P |
|---|---|---|---|---|---|---|
| Baseline WBC count (×1,000/μL) | 6.0 | 0.68 | 0.69 | 0.68 | 0.60–0.83 | <0.001 |
| Δ% of spleen volume after 12 mo | 0.3 | 0.93 | 0.90 | 0.91 | 0.80–0.98 | <0.001 |
| Δ% of WBC count after 12 mo | 0.2 | 0.54 | 0.90 | 0.72 | 0.62–0.83 | <0.001 |
↵* High sensitivity and specificity outperforming differences in baseline WBC levels and Δ% of WBC levels after 12 mo.
AUC = area under curve.