TABLE 4.

Diagnostic Performance for Lymph Node Disease in Control and Experimental Arms, Based on Histopathologic Data

Control armExperimental arm
StatisticIntermediateHighIntermediateHigh
Sensitivity—16.7% (0.4%–64.1%)—75% (47.6%–92.7%)
Specificity—92.1% (78.6%–98.3%)—75% (56.6%–88.5%)
Positive LR—2.11 (0.26–17.12)—3 (1.55–5.82)
Negative LR—0.90 (0.63–1.31)—0.33 (0.14–0.80)
PPV—25% (60%–80.6%)*—60% (36%–80.1%)†
NPV—87.5% (73.2%–95.8%)*—85.7% (67.3%–96%)†
Accuracy—81.8% (67.3%–91.8%)*—75% (60.4%–86.4%)†

  • ↵* Disease prevalence in population = 13.64%.

  • ↵† Disease prevalence in population = 33.33%.

  • LR = likelihood ratio; PPV = positive predictive value; NPV = negative predictive value.

  • Data in parentheses are 95% CIs.