TABLE 2.

Affinity of DPI-4452 for hCAIX

CompoundKD (nM)Dissociation half-life (min)
DPI-44520.2599
[natLu]Lu-DPI-44520.16123
[natGa]Ga-DPI-44520.2112

  • Affinities and dissociation kinetics were measured by surface plasmon resonance assay.