AEs During Treatment with 177Lu-DOTATATE
| AE | Initial treatment (n = 31) | Retreatment (n = 31) |
|---|---|---|
| Any key hematologic AE* | ||
| Any grade | 28 (90%) | 26 (84%) |
| Grade 3/4 | 1 (3%) | 4 (13%) |
| Leukopenia | ||
| Any grade | 15 (48%) | 15 (48%) |
| Grade 3/4 | 0 | 1 (3%) |
| Anemia | ||
| Any grade | 24 (77%) | 23 (74%) |
| Grade 3/4 | 0 | 1 (3%) |
| Neutropenia | ||
| Any grade | 5 (16%) | 5 (16%) |
| Grade 3/4 | 1 (3%) | 0 |
| Thrombocytopenia | ||
| Any grade | 20 (65%) | 19 (61%) |
| Grade 3/4 | 0 | 2 (6%) |
| Lymphopenia | ||
| Any grade | 29 (94%) | 26 (84%) |
| Grade 3/4 | 14 (45%) | 8 (26%) |
| High ALP | ||
| Any grade | 15 (48%) | 15 (48%) |
| Grade 3/4 | 1 (3%) | 0 |
| High ALT | ||
| Any grade | 16 (52%) | 10 (32%) |
| Grade 3/4 | 0 | 1 (3%) |
| High AST | ||
| Any grade | 14 (45%) | 8 (26%) |
| Grade 3/4 | 0 | 1 (3%) |
| Hypercreatininemia | ||
| Any grade | 6 (19%) | 6 (19%) |
| Grade 3/4 | 0 | 0 |
| Low eGFR | ||
| Any grade | 21 (68%) | 19 (61%) |
| Grade 3/4 | 0 | 0 |
↵* Key hematologic AEs included any leukopenia, anemia, neutropenia, and thrombocytopenia.
ALP = alkaline phosphatase; ALT = alanine aminotransferase; AST = aspartate aminotransferase; eGFR = estimated glomerular filtration rate.
AEs were measured from the date of the first cycle to 8 wk after the last cycle for each treatment phase.