TABLE 2.

Summary of Tumor Radiation Dose Estimations

Patient[177Lu]Lu-DOTATOC, 1 cycle*[177Lu]Lu-DOTA-JR11, 1 cycle2–3 cycles
Meningioma dose (Gy/cycle)Red marrow dose (Gy/cycle)T/BMT/KMeningioma dose (Gy/cycle)Red marrow dose (Gy/cycle)T/BM ratioT/K ratioMeningioma dose (Gy)
10.80.05160.64.70.16303.09.5
21.90.10190.68.40.31271.815.3
34.40.15281.514.50.27544.632.3
45.00.17300.915.00.39382.543.4
510.20.13784.022.70.34668.157.7
62.50.08291.07.10.24302.013.5
Median3.40.11291.011.50.29342.823.8
Range0.8–10.20.05–0.1716–780.6–4.04.7–22.70.16–0.3925–661.8–8.19.5–57.7
  • * First therapy cycle was performed with 7.4 GBq ± 10% [177Lu]Lu-DOTATOC.

  • All [177Lu]Lu-DOTA-JR11 therapy cycles were conducted with 2 GBq × body surface area ± 10% per cycle.

  • T/BM = tumor-to-red bone marrow ratio; T/K = tumor-to-kidney ratio.