TABLE 3.

Mean Model Parameters Obtained with 2T3k_V_B and Patlak Analysis Using [¹⁸F]FDG, Derived with IDIF_AA, IDIF_IC-IDM8i, and IDIF_IC-IDM12i

		2T3k_V_B					Patlak
Region	IDIF	V_B	K₁ (mL·cm⁻³·min⁻¹)	k₂ (min⁻¹)	k₃ (min⁻¹)	K_i (mL·cm⁻³·min⁻¹)	K_i (mL·cm⁻³·min⁻¹)	Y₀ (mL·cm⁻³)
White matter	IDIF_AA	0.020 (0.008)	0.04 (0.02)	0.09 (0.02)	0.036 (0.008)	0.010 (0.003)	0.008 (0.003)	0.32 (0.13)
	IDIF_IC-IDM8i	0.013 (0.006)^*	0.04 (0.02)^*	0.06 (0.01)^†	0.015 (0.005)^‡	0.008 (0.003)	0.008 (0.003)	0.50 (0.20)
	IDIF_IC-IDM12i	0.008 (0.003)^†	0.03 (0.01)^*	0.05 (0.01)^‡	0.016 (0.006)^‡	0.007 (0.003)^†	0.007 (0.003)^†	0.38 (0.16)^*
Gray matter	IDIF_AA	0.040 (0.005)	0.10 (0.01)	0.14 (0.02)	0.055 (0.005)	0.027 (0.004)	0.023 (0.003)	0.65 (0.08)
	IDIF_IC-IDM8i	0.029 (0.005)^†	0.10 (0.01)	0.07 (0.01)^‡	0.024 (0.005)^‡	0.026 (0.004)	0.023 (0.004)	1.04 (0.12)^‡
	IDIF_IC-IDM12i	0.018 (0.004)^‡	0.069 (0.01)^†^*	0.057 (0.01)^‡	0.026 (0.006)^‡	0.022 (0.003)^†	0.020 (0.003)^†	0.78 (0.12)^*
Whole brain	IDIF_AA	0.039 (0.004)	0.08 (0.01 s)	0.14 (0.02)	0.052 (0.005)	0.022 (0.003)	0.018 (0.002)	0.58 (0.06)
	IDIF_IC-IDM8i	0.028 (0.004)^†	0.09 (0.01)	0.08 (0.01)^‡	0.023 (0.005)^‡	0.021 (0.003)	0.018 (0.003)	0.91 (0.09)^‡
	IDIF_IC-IDM12i	0.018 (0.003)^‡	0.061 (0.008)^†	0.06 (0.01)^‡	0.025 (0.005)^‡	0.017 (0.002)^†	0.015 (0.002)^*	0.68 (0.08)^†

↵* P < 0.05, IDIF_AA vs. IDIF_IC.
↵† P < 0.01, IDIF_AA vs. IDIF_IC.
↵‡ P < 0.001, IDIF_AA vs. IDIF_IC.
Y₀ = Patlak intercept.
Data in parentheses are SDs.