TABLE 3.

Ex Vivo Biodistribution After Single Intravenous Injection of ¹⁷⁷Lu-RAYZ-8009 to Female Nude Mice Bearing HepG2 Xenografted Tumor

	Average %ID/g
Organ	1 h	2 h	6 h	24 h	48 h	96 h	192 h	288 h
Blood	0.54	0.03	0.01	0.01	0.01	0.00	0.00	0.00
Muscle	0.077	0.051	0.049	0.026	0.007	0.02	0.00	0.00
Tumor	25.28	19.77	16.08	16.63	16.39	8.76	2.56	2.38
Kidney	19.50	16.14	11.56	4.67	1.60	0.67	0.11	0.19
Adrenal glands	0.374	0.284	0.201	0.315	0.102	0.071	0.014	0.014
Heart	0.197	0.103	0.080	0.047	0.022	0.008	0.001	0.001
Lung	1.234	1.266	0.839	0.377	0.107	0.050	0.007	0.009
Spleen	0.314	0.273	0.348	0.285	0.740	0.075	0.028	0.116
Stomach	0.257	0.117	0.173	0.102	0.028	0.018	0.002	0.003
Uterus	1.097	0.269	0.325	0.189	0.071	0.058	0.026	0.043
Bladder wall	1.451	0.151	0.207	0.054	0.241	0.057	0.018	0.018
Bone	0.086	0.048	0.055	0.036	0.021	0.008	0.004	0.002
Bone marrow	0.228	0.104	0.067	0.176	0.139	0.025	0.003	0.000
Gallbladder	0.298	0.463	0.411	0.709	0.928	0.080	0.023	0.009
Cecum	0.106	0.402	0.573	0.575	1.621	0.456	0.095	0.159
Pancreas	0.279	0.308	0.175	0.076	0.023	0.009	0.001	0.000
Liver	0.263	0.133	0.090	0.463	0.159	0.060	0.020	0.044
Small intestine	0.403	1.126	0.138	0.415	0.208	0.077	0.022	0.184
Large intestine	0.532	0.621	0.451	0.634	1.872	0.306	0.107	0.248
Top half	0.326	0.227	0.186	0.143	0.047	0.016	0.003	0.006
Bottom half	1.235	0.250	0.183	0.246	0.097	0.055	0.012	0.017
Tail	1.645	0.506	0.234	0.593	0.120	0.057	0.015	0.166
Tumor-to-kidney ratio	1.29	1.25	1.76	3.69	11.33	15.04	22.29	12.37
Tumor-to-liver ratio	108.74	244.41	189.66	62.96	104.80	148.36	145.51	55.89

Top half = remaining tissues not collected from diaphragm to top of head; bottom half = remaining tissues not collected from directly below diaphragm to base of tail.