Baseline Demographics and Clinical Characteristics
| Aβ− (n = 15) | LO+ (n = 20) | EO+ (n = 17) | Others (n = 2) | P | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | Aβ− CN | Aβ− MCI | Aβ+ MCI | Aβ+ AD | Aβ+ MCI | Aβ+ AD | Aβ+ CN | Aβ− AD | All | Aβ− vs. LO+ | Aβ− vs. EO+ | LO+ vs. EO+ |
| n | 7 | 8 | 9 | 11 | 11 | 6 | 1 | 1 | ||||
| Age (y) | 64.0 ± 10.1 | 72.6 ± 7.1 | 75. 1 ± 3.8 | 78.0 ± 3.9 | 61.8 ± 5.3 | 65.8 ± 6.0 | 72 | 65 | <0.001* | 0.002* | 0.073 | <0.001* |
| Age at onset (y) | 70.4 ± 4.5 | 73.2 ± 4.0 | 57.9 ± 5.4 | 57.7 ± 5.3 | 64 | <0.001* | <0.001* | <0.001* | ||||
| Education (y) | 11.1 ± 2.9 | 10.9 ± 3.9 | 11.6 ± 2.4 | 12.5 ± 4.3 | 11.6 ± 4.8 | 10.2 ± 3.9 | 7 | 16 | 0.631 | |||
| Male-to-female ratio | 2:5 | 4:4 | 3:6 | 5:6 | 3:8 | 1:5 | 0:1 | 0:1 | 0.504 | |||
| HTN (%) | 57.1 | 62.5 | 44.4 | 72.7 | 27.3 | 50 | 0 | 0 | 0.247 | |||
| DM (%) | 0 | 0 | 11.1 | 36.4 | 18.2 | 0 | 0 | 0 | 0.097 | |||
| Hyperlipidemia (%) | 42.9 | 50 | 44.4 | 27.3 | 18.2 | 33.3 | 100 | 0 | 0.389 | |||
| ApoE ε4 carrier (%) | 57.1 | 12.5 | 55.6 | 63.6 | 72.7 | 66.7 | 0 | 0 | 0.094 | |||
| FU interval (mo) | 11.6 ± 1.1 | 12.1 ± 0.8 | 12.2 ± 1.1 | 11.7 ± 0.7 | 12.1 ± 0.9 | 11.8 ± 0.1 | 12 | 12 | 0.913 | |||
↵* Statistically significant at P < 0.05.
HTN = hypertension; DM = diabetes mellitus; ApoE = apolipoprotein E; FU = follow-up.
Data are shown as mean ± SD for continuous variables and percentages for categoric variables.