TABLE 2.

Diagnostic Metrics for Imaging Modalities

Metric68Ga-PSMA-11 PET/CTmpMRIP*68Ga-PSMA-11 PET/CT and mpMRIP†
Any cancer
 Sensitivity0.89 (0.78–0.98)0.72 (0.61–0.83)0.10.98 (0.92–1.00)0.003
 Specificity0.67 (0.48–0.86)0.64 (0.44–0.83)10.45 (0.27–0.67)0.07
 PPV0.81 (0.67–0.93)0.76 (0.62–0.90)0.40.74 (0.61–0.87)0.6
 NPV0.79 (0.62–0.95)0.59 (0.41–0.75)0.070.93 (0.75–1.00)<0.001
Definition 1 cancer
 Sensitivity0.87 (0.75–0.97)0.76 (0.64–0.86)0.40.97 (0.91–1.00)0.01
 Specificity0.65 (0.47–0.83)0.65 (0.46–0.84)10.44 (0.27–0.63)0.04
 PPV0.77 (0.60–0.90)0.74 (0.59–0.89)0.70.70 (0.54–0.84)0.3
 NPV0.79 (0.62–0.95)0.67 (0.48–0.83)0.30.93 (0.75–1.00)0.006
Definition 2 cancer
 Sensitivity0.88 (0.77–0.97)0.75 (0.64–0.86)0.30.98 (0.92–1.00)0.007
 Specificity0.67 (0.48–0.86)0.64 (0.44–0.83)10.45 (0.27–0.67)0.07
 PPV0.80 (0.65–0.93)0.76 (0.61–0.90)0.50.73 (0.58–0.86)0.5
 NPV0.79 (0.62–0.95)0.63 (0.45–0.80)0.20.93 (0.75–1.00)0.002

  • ↵* Comparison of PET/CT against MRI.

  • ↵† Comparison of PET/CT and MRI combined against MRI alone.

  • Data in parentheses are 95% CI.