TABLE 3.

Association Between Relative Change in 68Ga-DOTATATE PET/CT Parameters After C1 from Baseline and Morphologic Lesion Outcome

ParameterResponseLesions (n)MedianIQRP*Spearman ρP
SUVmaxR19−23%−33% to 0%0.48
NR59−16%−33% to 0%
SUVmeanR19−21%−39% to 3%0.29
NR59−15%−29% to 5%
Tumor-to-spleen ratioR14−32%−41% to −8%0.91
NR54−30%−50% to −12%
Tumor-to-blood ratioR19−18%−35% to 3%0.44
NR59−16%−31% to 19%
SSTR TVR19−9%−36% to 20%0.050.27 (95% CI, 0.05 to 0.47)0.01
NR5911%−8% to 27%
Total lesion SSTR expressionR19−27%−46% to −3%0.010.32 (95% CI, 0.11 to 0.51)0.004
NR59−6%−24% to 11%
  • * Grouped analysis using Wilcoxon signed-rank test.

  • Spearman rank correlation.

  • R = responding lesion; NR = nonresponding lesion.