Accuracy of Estimating Age from 18F-FDG PET and MRI Scans
| Parameter | Modality | n | MAE | Range | BAG | R2 | Accuracy (MAE MRI vs. 18F-FDG PET) | Generalizability (MAE current vs. ADNI CN) | Brain age advancement (BAG current vs. ADNI CN) |
|---|---|---|---|---|---|---|---|---|---|
| ADNI CN | MRI | 175* | 2.49 | −9.4 to 8.7 | 0.06 | 0.74 | t = 0.48 (−0.33 to 0.55) | NA | NA |
| 18F-FDG PET | 175* | 2.60 | −10.1 to 9.6 | −0.10 | 0.70 | NA | |||
| OASIS CN | MRI | 49* | 2.92 | −7.1 to 8.4 | 0.13 | 0.42 | t = −0.94 (−1.20 to 0.43) | t = 1.16 (−0.31, 1.18) | t = 0.12 (−1.12, 1.26) |
| 18F-FDG PET | 49* | 2.54 | −5.0 to 6.8 | 0.89 | 0.63 | t = −0.18 (−0.64, 0.53) | t = 2.00† (0.01, 1.97) | ||
| ADNI SCD | MRI | 102 | 2.50 | −6.6 to 7.0 | 0.11 | 0.69 | t = 0.26 (−0.42 to 0.54) | NA | t = 0.11 (−0.73, 0.82) |
| 18F-FDG PET | 102 | 2.56 | −5.6 to 9.8 | 0.64 | 0.69 | NA | t = 1.86‡ (−0.05, 1.53) | ||
| ADNI MCI | MRI | 595 | 3.30 | −10.5 to 13.5 | 2.16 | 0.65 | t = −5.72¶ (0.95 to 0.46) | NA | t = 7.47¶ (1.55, 2.65) |
| 18F-FDG PET | 595 | 2.59 | −10.0 to 11.0 | 0.55 | 0.78 | NA | t = 2.23† (0.08, 1.22) | ||
| DELCODE SCD | 18F-FDG PET | 88 | 3.16 | −2.7 to 9.3 | 2.77 | 0.52 | NA | NA | t = 7.45¶ (2.11, 3.63) |
| DELCODE MCI | MRI | 80 | 3.69 | −5.1 to 11.6 | 2.89 | 0.38 | NA | NA | t = 6.04¶ (1.90, 3.75) |