Injected Activity of 225Ac, 177Lu, or 90Y Necessary to Reach TCP of 90% for Modified Activity Distribution
| Radioactivity | 225Ac (kBq) | 177Lu (MBq) | 90Y (MBq) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Radiosensitivity (Gy−1) | 0.5 | 1.0 | 1.3 | 2.0 | 0.1 | 0.2 | 0.3 | 0.4 | 0.1 | 0.2 | 0.3 | 0.4 |
| Tumor 1 | — | 90 | 34 | 29 | 78 | 39 | 26 | 20 | 11 | 6 | 4 | 3 |
| Tumor 2 | — | 80 | 31 | 27 | 66 | 35 | 23 | 18 | 12 | 6 | 4 | 3 |
| Tumor 3 | — | 86 | 66 | 42 | — | 77 | 52 | 39 | 14.5 | 7.5 | 5 | 4 |
Calculations were made for ranges of radiosensitivity of 0.5, 1.0, 1.3, and 2.0 Gy−1 for 225Ac and 0.1, 0.2, 0.3, and 0.4 Gy−1 for 177Lu and 90Y.