LogP and Binding Affinities
| Compounds | HPLC LogP | Binding affinities | |||
|---|---|---|---|---|---|
| Tau aggregates* | Amyloid aggregates | MAO-A | MAO-B | ||
| SNFT-1 | 1.34 | 0.84 | >1,000 | >1,000 | >1,000 |
| MK-6240 | 2.11 | 0.64 | >1,000 | >1,000 | >1,000 |
| PM-PBB3 | 2.00 | 28.4 (14.4 nM†) | 12.8 | >1,000 | >1,000 |
| PI-2620 | 1.34 | 1.32 | >1,000 | >1,000 | >1,000 |
| JNJ-067 | 2.38 | 1.07 | >1,000 | 568 | 58.9 |
| RO948 | 1.19 | 1.63 | >1,000 | >1,000 | 249 |
| THK-5351 | 1.28 | 19.0 | 771 | >1,000 | 5.2 |
| Flortaucipir | 1.65 | 0.28 | >1,000 | 8.8 | 55.3 |
| T808 | 1.96 | 2.16 | >1,000 | >1,000 | >1,000 |
| FDDNP | 3.68 | 693 | 902 | >1,000 | 6.5 |