[177Lu]-PSMA-I&T RLT Emergent Toxicities
| Toxicity | Entire cohort | Chemotherapy-naïve patients | Chemotherapy-pretreated patients | P* |
|---|---|---|---|---|
| Hematologic toxicities | ||||
| Anemia | ||||
| All grades | 37 (46.3%) | 23 (46.9%) | 14 (45.2%) | 0.64 |
| Grade 3 or 4 | 4 (5.0%) | 1 (2.0) | 3 (9.7%) | |
| Leukocytopenia | ||||
| All grades | 12 (15.0%) | 5 (10.2%) | 7 (22.6%) | 0.18 |
| Grade 3 or 4 | 0 (0%) | 0 (0%) | 0 (0%) | |
| Thrombocytopenia | ||||
| All grades | 13 (16.3%) | 7 (14.3%) | 6 (19.4%) | 0.20 |
| Grade 3 or 4 | 3(3.8%) | 1 (2.0%) | 2 (6.5%) | |
| Renal toxicity | ||||
| Estimated glomerular filtration rate | ||||
| All grades | 20 (25%) | 15 (30.6%) | 5 (16.1%) | 0.29 |
| Grade 3 or 4 | 4 (5.0%) | 2 (4.1%) | 2 (6.5%) | |
| Nonhematologic toxicities | ||||
| Xerostomia | ||||
| All grades | 26 (32.5%) | 19 (38.8%) | 7 (22.6%) | 0.39 |
| Grade 3 | 0 (0%) | 0 (0%) | 0 (0%) | |
| Fatigue | ||||
| All grades | 26 (32.5%) | 14 (28.6%) | 12 (38.7%) | 0.53 |
| Grade 3 or 4 | 0 (0%) | 0 (0%) | 0 (0%) | |
| Loss of appetite | ||||
| All grades | 16 (20.0%) | 11 (22.4%) | 5 (16.1%) | 0.79 |
| Grade 3 or 4 | 0 (0%) | 0 (0%) | 0 (0%) | |
| Diarrhea | ||||
| All grades | 4 (5.0%) | 4 (8.2%) | 0 (0%) | 0.70 |
| Grade 3 or 4 | 0 (0%) | 0 (0%) | 0 (0%) | |
| Constipation | ||||
| All grades | 7 (8.8%) | 6 (12.2%) | 1 (3.2%) | 0.91 |
| Grade 3 or 4 | 0 (0%) | 0 (0%) | 0 (0%) | |
| Nausea | ||||
| All grades | 2 (2.5%) | 2 (4.1%) | 1 (3.2%) | 0.89 |
| Grade 3 or 4 | 0 (0%) | 0 (0%) | 0 (0%) |
↵* χ2 test.