Comparison of SUVmax on 68Ga-FAPI-RGD and 68Ga-FAPI-46 PET/CT Images in Primary and Metastatic Lesions
| Tumor type | n | Tumor size (cm) | Tracer | Positive lesions (n) | SUVmax | TBR | ||
|---|---|---|---|---|---|---|---|---|
| Median | P | Median | P | |||||
| Primary tumors | ||||||||
| NPC | 1 | 2.4 (NA) | 68Ga-FAPI-RGD | 25.8 | NA | 15.2 | NA | |
| 68Ga-FAPI-46 | 14.5 | 7.6 | ||||||
| SCLC | 1 | 4.8 (NA) | 68Ga-FAPI-RGD | 9.2 | NA | 6.1 | NA | |
| 68Ga-FAPI-46 | 5.8 | 3.4 | ||||||
| Pancreatic cancer | 1 | 4.3 (NA) | 68Ga-FAPI-RGD | 36.3 | NA | 51.9 | NA | |
| 68Ga-FAPI-46 | 31.1 | 38.9 | ||||||
| Total | 3 | 4.3 (2.4–4.8) | 68Ga-FAPI-RGD | 25.8 (9.2–36.3) | 0.109 | 15.2 (6.1–51.9) | 0.109 | |
| 68Ga-FAPI-46 | 14.5 (5.8–31.1) | 7.6 (3.4–38.9) | ||||||
| Metastases | ||||||||
| Lymph node mets (total) | 46 | 1.1 (0.6–2.8) | 68Ga-FAPI-RGD | 46 | 15.5 (4.3–27.1) | <0.001 | 13.2 (3.3–38.7) | <0.001 |
| 68Ga-FAPI-46 | 46 | 8.7 (3.3–23.3) | 8.1 (2.7–18.2) | |||||
| Brain mets | 4 | 0.7 (0.4–0.7) | 68Ga-FAPI-RGD | 4 | 5.8 (4.0–8.3) | 0.068 | 143.8 (80.0–207.5) | 0.068 |
| 68Ga-FAPI-46 | 4 | 3.0 (2.5–4.2) | 83.7 (65.0–85.0) | |||||
| Lung mets | 15 | 1.1 (0.5–1.4) | 68Ga-FAPI-RGD | 13 | 9.5 (2.0–15.7) | 0.004 | 18.8 (2.0–39.3) | 0.003 |
| 68Ga-FAPI-46 | 13 | 6.4 (1.6–13.3) | 12.5 (1.6–33.3) | |||||
| Liver mets | 7 | 1.1 (0.6–1.4) | 68Ga-FAPI-RGD | 7 | 6.9 (3.9–16.8) | 0.028 | 6.3 (3.6–16.8) | 0.028 |
| 68Ga-FAPI-46 | 4 | 3.4 (1.8–16.2) | 3.4 (1.8–16.2) | |||||
| Subcutaneous mets | 5 | 0.8 (0.7–0.9) | 68Ga-FAPI-RGD | 5 | 8.6 (6.6–10.0) | 0.138 | 7.2 (5.5–10.0) | 0.08 |
| 68Ga-FAPI-46 | 5 | 7.2 (6.1–9.0) | 5.1 (3.6–8.2) | |||||
| Bone mets | 29 | 1.2 (0.5–8.2) | 68Ga-FAPI-RGD | 29 | 13.7 (6.1–27.6) | <0.001 | 14.5 (6.3–27.6) | <0.001 |
| 68Ga-FAPI-46 | 25 | 6.8 (1.2–19.6) | 6.3 (1.8–21.8) | |||||
NPC = nasopharyngeal carcinoma; NA = not applicable; SCLC = small lung cancer; mets = metastases.
Data in parentheses are ranges.