Organ-Absorbed Doses from [64Cu]Cu-SARTATE and [67Cu]Cu-SARTATE
| Mean absorbed dose (mGy/MBq) | |||
|---|---|---|---|
| Organ | [64Cu]Cu- SARTATE | [67Cu]Cu- SARTATE | 67Cu/64Cu ratio (mGy) |
| Adrenals | 8.30 × 10−2 | 1.79 × 10−1 | 2.2 |
| Brain | 1.29 × 10−2 | 4.12 × 10−2 | 3.2 |
| Breasts | 1.32 × 10−2 | 3.85 × 10−2 | 2.9 |
| Gallbladder wall | 2.42 × 10−2 | 5.43 × 10−2 | 2.2 |
| LLI wall | 3.68 × 10−2 | 1.13 × 10−1 | 3.1 |
| Small intestine | 5.00 × 10−2 | 1.58 × 10−1 | 3.2 |
| Stomach wall | 2.07 × 10−2 | 4.88 × 10−2 | 2.4 |
| ULI wall | 2.00 × 10−2 | 5.14 × 10−2 | 2.6 |
| Heart wall | 2.06 × 10−2 | 5.42 × 10−2 | 2.6 |
| Kidneys | 2.46 × 10−1 | 5.45 × 10−2 | 2.2 |
| Liver | 9.90 × 10−2 | 1.73 × 10−1 | 1.7 |
| Lungs | 3.85 × 10−2 | 8.50 × 10−2 | 2.2 |
| Muscle | 1.56 × 10−2 | 2.54 × 10−2 | 1.6 |
| Ovaries | 1.79 × 10−2 | 4.85 × 10−2 | 2.7 |
| Pancreas | 4.12 × 10−2 | 7.98 × 10−2 | 1.9 |
| Red marrow | 2.11 × 10−2 | 6.19 × 10−2 | 2.9 |
| Osteogenic cells | 3.22 × 10−2 | 1.30 × 10−1 | 4.0 |
| Skin | 1.20 × 10−2 | 3.66 × 10−2 | 3.0 |
| Spleen | 4.78 × 10−1 | 6.42 × 10−1 | 1.3 |
| Testes | 1.19 × 10−2 | 4.08 × 10−2 | 3.4 |
| Thymus | 1.46 × 10−2 | 4.08 × 10−2 | 2.8 |
| Thyroid | 1.35 × 10−2 | 5.34 × 10−2 | 3.9 |
| Urinary bladder wall | 3.81 × 10−2 | 6.22 × 10−2 | 1.6 |
| Uterus | 1.77 × 10−2 | 5.23 × 10−2 | 3.0 |
| Total body | 2.32 × 10−2 | 5.19 × 10−2 | 2.2 |
LLI = lower large intestine; ULI = upper large intestine.
Data are mean of 3 subjects. [67Cu]Cu-SARTATE estimates are based on all 4 cycles estimated independently in each subject and then averaged across all 3 subjects. Mean effective dose was 3.95 × 10−2 mSv/MBq for [64Cu]Cu-SARTATE and 7.62 × 10−2 mSv/MBq for[67Cu]Cu-SARTATE.