TABLE 2.

Uni- and Multivariable Analysis for Association of Baseline Variables with OS

		Univariable analysis			Multivariable analysis
Variable	No. of patients	HR	95% CI	P	HR	95% CI	P
High scintigraphic uptake	295
No	96	Reference
Yes	199	0.9	0.6–1.2	0.3	0.8	0.6–1.1	0.2
Age, continuous	295	1.0	1.0–1.0	0.3	1.0	1.0–1.0	0.6
AP per 50 U/L increase, continuous	295	1.0	1.0–1.1	0.0001^*	1.0	1.0–1.1	0.02^*
LDH per 50 U/L increase, continuous	295	1.0	1.0–1.1	<0.0001^*	1.0	1.0–1.1	0.001^*
Hemoglobin, continuous	295	1.0	1.0–1.0	0.7	1.0	1.0–1.0	0.4
PSA per 50 ng/mL increase, continuous	295	1.0	1.0–1.0	0.0001^*	1.0	1.0–1.0	0.01^*
≥2 pretreatments	295
No	98	Reference
Yes	197	1.4	1.0–1.9	0.1	1.3	0.8–2.0	0.3
Previous ²²³Ra	295
No	254	Reference
Yes	41	1.0	0.7–1.5	0.9	0.8	0.5–1.2	0.3
Previous chemotherapy	295
No	84	Reference
Yes	211	1.5	1.1–2.2	0.02^*	1.1	0.7–1.7	0.7
Bone metastases (M1b, without visceral metastases)	211	Reference			Reference
Lymph node only metastases (N+/M1a)	21	0.3	0.1–0.7	0.007^*	0.4	0.2–1.0	0.05
Visceral metastases (M1c)	63	1.5	1.1–2.0	0.03^*	1.5	1.0–2.1	0.02^*