Sensitivity and Specificity of MK-6240 Visual Reads and SUVr Analyses Using Clinical Diagnosis as Standard of Truth
| Method | Sensitivity | Specificity | Youden index |
|---|---|---|---|
| Visual read | |||
| Reader 0 | 0.79 | 0.93 | 0.72 |
| Reader 1 | 0.75 | 0.93 | 0.68 |
| Reader 2 | 0.79 | 0.91 | 0.70 |
| Consensus | 0.81 | 0.93 | 0.74 |
| Visual VRES (cutoff, 1.5) | 0.742 | 0.890 | 0.63 |
| SUVr | |||
| Braak 1–2 (cutoff, 1.4) | 0.649 | 0.888 | 0.54 |
| Braak 3–4 (cutoff, 1.3) | 0.645 | 0.963 | 0.61 |
| Braak 5–6 (cutoff, 1.2) | 0.611 | 0.960 | 0.57 |
| Jack VOI (cutoff, 1.4) | 0.650 | 0.880 | 0.53 |
Jack VOI = VOI regions of Jack et al. (15).