TABLE 1.

Opportunities and Challenges Ahead for Nuclear Medicine Toward Achieving Trustworthy AI

CategoryDomainSubdomain
OpportunitiesDiagnostic imagingEmerging nuclear imaging approaches
RPTsAI-driven theranostic drug discovery and labeling
Precision dosimetry
Predictive dosimetry and digital twins
Clinical workflow: increasing throughput while maintaining excellence
ChallengesDevelopment of AI applications/medical devicesData
Optimal network architecture
Measurement and communication of uncertainty
Clinically impactful use cases
Team science
Evaluation (verification of performance)Performance profiling through task-based evaluations
Guidelines for validation
Multicenter clinical trial network
Ethical, regulatory, and legal ambiguitiesEthical aspects
Regulatory and legal aspects
Implementation of clinical AI solutions and postimplementation monitoringAI platform
Barriers of dissemination and implementation of AI technology in medicine
Postdeployment: change management and performance
Trust and trustworthiness