Some Tauopathies and Their Brain Targets
| Disease | Tau isoform | Primary pathology | Brain localization | Regions with highest PET uptake |
|---|---|---|---|---|
| AD | 3R,4R | Paired helical filaments | Cortical | Temporal, postcingulate |
| Progressive supranuclear palsy | 4R | Straight filaments | Subcortical | Globus pallidus, putamen, subthalamic nucleus |
| Corticobasal degeneration | 4R | Straight filaments | Subcortical | Globus pallidus, putamen |
| Chronic traumatic encephalopathy | 3R,4R | Paired helical filaments | Cortical | Frontal, temporal, diencephalon |
| Down syndrome | 3R,4R | Paired helical filaments | Cortical | Temporal, postcingulate |