Patient no. | Sex | Age (y) | Disease | State of disease before RLT | Additional radioimmunotherapy | HSCT | RLT to neutropenia (d) | HSCT to neutrophil reconstitution (d) | Best response | PFS | OS |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | F | 50 | T-PLL | PD | No | Allogeneic | 10 | NA* | NA* | NA* | 16 d |
2 | M | 53 | TCL (NOS) | PD | No | Autologous | 11 | NA† | PR | 7 mo | 56 mo |
3 | M | 50 | TCL (hepatosplenic/NOS) | PD | Yes (188Re) | Allogeneic | 11 | 12 | CMR | 25 mo | 54 mo‡ |
4 | F | 43 | T-cell lymphoblastic lymphoma | PD | No | Allogeneic | 14 | 12 | CMR | 4 mo‡ | 4 mo‡ |
* Patient 1 died after RLT and HSCT, without reaching neutrophil reconstitution.
↵†Neutrophil reconstitution was not immediately successful after autologous HSCT but was reached after another conditioning therapy and allogeneic HSCT.
↵‡Complete metabolic response at last available follow-up.
PFS = progression-free survival; OS = overall survival; T-PLL = T-cell prolymphocytic leukemia; PD = progressive disease; NA = not available; NOS = not otherwise specified; PR = partial response; CMR = complete metabolic response.
Patients 2–4 were alive at last available follow-up.