TABLE 3.

Multivariate Analysis of Survival at 3-Year Follow-Up

Overall survivalCancer-specific survival
CharacteristicHazard ratioPGlobal PHazard ratioPGlobal P
Age category (y)
 66–69 (ref)0.0066*0.0079*
 70–740.988 (0.90–1.08)0.79920.940 (0.85–1.04)0.2436
 ≥751.115 (1.02–1.22)0.0157*1.089 (0.99–1.20)0.0901
Sex
 Male (ref)0.0012*0.0008*
 Female0.886 (0.82–0.95)0.0012*0.869 (0.80–0.94)0.0008*
Facility type
 National Cancer Institute center (ref)0.0174*0.0191*
 Other/no hospital1.151 (1.02–1.30)0.0205*1.164 (1.02–1.33)0.0280*
 Teaching hospital1.050 (0.93–1.18)0.42131.047 (0.91– 0.20)0.5064
Derived AJCC stage group, sixth edition
 Stage I (ref)<0.0001*<0.0001*
 Stage II1.906 (1.62–2.25)<0.0001*1.920 (1.59–2.31)<0.0001*
 Stage III2.057 (1.67–2.54)<0.0001*2.135 (1.70–2.69)<0.0001*
 Stage IVA2.810 (2.11–3.74)<0.0001*2.846 (2.08–3.89)<0.0001*
Initial treatment
 Radiation (ref)<0.0001*<0.0001*
 Chemotherapy0.681 (0.58–0.80)<0.0001*0.696 (0.58–0.83)<0.0001*
 Chemotherapy and RT0.533 (0.42–0.67)<0.0001*0.537 (0.42–0.69)<0.0001*
 Chemotherapy and surgery0.278 (0.20–0.38)<0.0001*0.272 (0.19–0.38)<0.0001*
 Chemotherapy, surgery, and RT0.337 (0.23–0.49)<0.0001*0.330 (0.22–0.50)<0.0001*
 Surgery0.673 (0.59–0.76)<0.0001*0.675 (0.58–0.78)<0.0001*
 Surgery and RT0.466 (0.34–0.63)<0.0001*0.415 (0.29–0.59)<0.0001*
Histologic subtype of NSCLC
 Adenocarcinoma (ref)<0.0001*0.0005*
 Adenosquamous1.471 (1.17–1.85)0.0010*1.392 (1.07–1.81)0.0138*
 Large cell carcinoma1.416 (1.11–1.81)0.0059*1.315 (1.00–1.72)0.0470*
 Neuroendocrine1.375 (1.02–1.85)0.0342*1.455 (1.05–2.01)0.0232*
 Squamous cell carcinoma1.719 (1.40–2.11)<0.0001*1.644 (1.32–2.05)<0.0001*
 Other/not specified1.728 (1.34–2.23)<0.0001*1.687 (1.28–2.22)0.0002*
Diagnostic imaging category
 Any PET (ref)<0.0001*0.0001*
 CT/CTA alone2.089 (1.55–2.81)<0.0001*1.986 (1.45–2.73)<0.0001*
 No related imaging0.438 (0.27–0.72)0.0011*0.448 (0.26–0.77)0.0039*
Imaging category before subsequent RT
 Any PET (ref)<0.0001*<0.0001*
 CT/CTA alone1.417 (1.32–1.52)<0.0001*1.430 (1.32–1.55)<0.0001*

  • ↵* Statistically significant (P < 0.05).

  • AJCC = American Joint Committee on Cancer.

  • Hazard ratios are lower confidence limit to upper confidence limit.