TABLE 2.

Toxicity (New Events) After 6 Cycles of 177Lu-PSMA RLT and Additional Events During Extended Treatment

Grade ≤ 2
ParameterCycles 1–6Extended treatment
Anemia13 (50%)5 (19%)
Leukopenia0 (0%)2 (8%)
Thrombocytopenia5 (19%)4 (15%)
Renal toxicity (chronic kidney disease)5 (19%)3 (12%)
Hepatotoxicity1 (4%)1 (4%)
Dry mouth12 (46%)4 (15%)
Adverse event that led to reduction in 177Lu-PSMA-617 dose0 (0%)2 (8%)
Adverse event that led to discontinuation of 177Lu-PSMA-6170 (0%)1 (4%)
Adverse event that led to death0 (0%)0 (0%)
  • No toxicities of grade 3 or higher were observed.