PET/CT Image Findings and Ex Vivo Tissue Factor Measurements
| Patient | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Characteristic | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| Primary tumor | Pancreas | Pancreas | Pancreas | Pancreas | Lung∥ | Lung | Breast | Breast | Cervix | Breast |
| Radiotracer mass (mg) | 0.84 | 0.69 | 0.71 | 0.71 | 0.74 | 0.41 | 0.76 | 0.56 | 0.74 | 0.58 |
| Injected activity (MBq) | 135 | 187 | 198 | 189 | 93 | 169 | 145 | 187 | 117 | 145 |
| Specific activity* (MBq/mg) | 161 | 271 | 279 | 266 | 126 | 412 | 191 | 334 | 158 | 250 |
| Metastases (Pathology/PET/CT)† | ÷/÷/÷ | ÷/÷/÷ | ÷/÷/÷ | ÷/÷/÷ | +/+/+ | ÷/÷/÷ | ÷/÷/÷ | ÷/÷/÷ | ÷/÷/÷ | +/÷/÷¶ |
| Tumor size (cm) | 3.6 × 3.3 | 3.5 × 3.1 | 4.9 × 3.8 | 2.6 × 2.2 | 1.2 × 0.9∥ | 3.6 × 3.4 | 2.8 × 1.4 | 0.7 × 0.8 | 3.2 × 2.9 | 2.4 × 1.4 |
| Tumor SUVmax | ||||||||||
| 1 h | 3.04 | 1.50 | 3.04 | 3.45 | 1.22∥ | 1.82 | 0.49 | 0.25 | 1.37 | 1.90# |
| 2 h | 2.14 | 1.74 | 3.23 | 4.04 | 1.81∥ | 1.80 | 0.31 | 0.19 | 1.74 | 2.18# |
| 4 h | 3.03 | 1.79 | 5.44 | 4.71 | 3.08∥ | 1.61 | 0.69 | 0.25 | 1.82 | 2.86# |
| Tumor SUVmean | ||||||||||
| 1 h | 1.41 | 0.85 | 1.67 | 1.93 | 0.83∥ | 0.70 | 0.30 | 0.20 | 0.75 | 1.19# |
| 2 h | 1.38 | 0.96 | 1.73 | 2.24 | 1.19∥ | 1.26 | 0.21 | 0.15 | 0.92 | 1.21# |
| 4 h | 1.68 | 0.98 | 2.94 | 2.62 | 1.97∥ | 1.18 | 0.40 | 0.15 | 1.01 | 1.73# |
| ΔT (d)‡ | 42 | 4 | NA | 6 | NA | NA | 12 | 5 | 6 | 4 |
| TFtumor (μg/mg) | NA | 5.93 | NA | 25.75 | NA | NA | 1.14 | NA | 1.27** | PT: 0.67 MET: NA |
| TFtumor IHC§ | Low** | Intermediate | NA | High | NA | NA | Low | Low | Low** | PT: Low/ intermediate†† |
| MET: Low | ||||||||||
| TFplasma (μg/L) | 61 | 54 | 56 | 72 | 73 | 43 | 82 | 66 | 21 | 73 |
* At time of injection.
↵†Presence of metastases based on pathology, PET, and CT, respectively.
↵‡Time between imaging and tissue collection.
↵§TF expression on immunohistochemistry (IHC) rated low, intermediate, or high based on visual assessment.
↵∥Primary tumor removed. SUV and size measured on metastasis.
↵¶No lymph node enlargement on CT and no apparent focal accumulation on PET.
↵#Heterogeneous radiotracer accumulation observed.
** Samples from biopsies.
↵††Low TF staining on IHC on tissue sample also showing low (0.67 μg/mg) TF expression. Tissue from full mastectomy, obtained from postpathology evaluation, with intermediate TF expression on IHC.
+ = metastases present; ÷ = no metastases; MET = metastases; NA = not available; PT = primary tumor.