Template-Based Analysis
| 18F-rhPMSA-7.3 PET/CT rating | Histology: lymph node metastasis | Proportions | |
|---|---|---|---|
| Positive | Negative | ||
| Combined data for 18F-rhPSMA-7 and 18F-rhPSMA-7.3 | |||
| Positive | 61 | 5 | PPV: 92.4% (95% CI, 83.3%–96.8%) |
| Negative | 14 | 70 | NPV: 83.3% (95% CI, 72.2%–90.6%) |
| Total | 75 | 75 | 150 |
| Sensitivity: 81.3% (95% CI, 70.1%–89.0%) | Specificity: 93.3% (95% CI, 85.9%–97.0%) | Accuracy: 87.3% (95% CI, 80.5–92.0) | |
| Morphologic imaging (CT/MRI) | |||
| Positive | 9 | 0 | PPV: 100% (95% CI, N/A) |
| Negative | 66 | 75 | NPV: 53.2% (95% CI, 44.5%–61.6%) |
| Total | 75 | 75 | 150 |
| Sensitivity: 12.0% (95% CI, 6.3%–21.6%) | Specificity: 100% (95% CI, N/A) | Accuracy: 64.5% (95% CI, 47.2%–64.5%) | |
Scores ≥ 4 in PET and morphologic imaging rated positive.
NPV = negative predictive value; N/A = not available as cannot be calculated (there exists no CI for point estimator of 1 in a generalized estimating equation).