Physical Characteristics of the Commonly Used Theranostics Pairs 68Ga/177Lu and 68Ga/90Y
| Physical characteristics* | |||||
|---|---|---|---|---|---|
| Energy [keV] | |||||
| Radionuclides | Gamma | Beta or Alpha | Half-life | Pharmaceuticals† | Use |
| 68Ga | 511 (caused by annihilation) | 1899 (β+) | 1.13 h | [68Ga]Ga-PSMA-11 [68Ga]Ga-PSMA-I&T [68Ga]Ga-DOTA-TATE (NETSPOTTM) [68Ga]Ga-DOTA-TOC (SomaKIT TOC®) | Diagnostic |
| 18F | 511 (caused by annihilation) | 634 (β+) | 1.83 h | Piflufolastat F18 (Pylarify®) [18F]F PSMA-1007 [18F]DCFPyL | |
| 177Lu | 113 (6%) 208 (11%) | 498 (β−) | 6.73 d | [177Lu]Lu-PSMA-617 [177Lu]Lu-PSMA-I&T [177Lu]Lu-DOTA-TATE (Lutathera®) | Therapy |
| 90Y | Bremsstrahlung | 2280 (β−) | 2.67 d | [90Y]Y-DOTA-TOC | |
| 99mTc | 140 (89%) | not relevant | 6.01 h | [99mTc]Tc-MDP [99mTc]Tc-DPD [99mTc]Tc-HDP | Diagnostic |
| 223Ra | 154 (6%) 269 (14%) | 5716 (α), 5606 (α), 6819 (α), 7386 (α), 6623 (α) 1370 (β−) 1420 (β−) | 11.44 d | 223RaCl2 (Xofigo®) | Therapy |
↵* Data are extracted from The Lund/LBNL Nuclear Data Search V 2.0 (http://nucleardata.nuclear.lu.se/toi/).
↵† Without claim to completeness.