Definitions of Criteria
| Criterion | Definition |
|---|---|
| NL (new lesions) | Appearance of at least 1 new PSMA-positive lesion on iPET, which was defined as any new focal uptake of PSMA ligand higher than surrounding background, and each tumor SUVmax > mean SUVmean |
| RECIP | |
| RECIP-CR | Absence of any PSMA uptake on iPET |
| RECIP-PR | PSMA-VOL_PR without appearance of new lesions |
| RECIP-PD | PSMA-VOL_PD with appearance of new lesions |
| RECIP-SD | Insufficient decline in PSMA-VOL to qualify for PSMA-VOL_PR or PSMA-VOL_PR with appearance of new lesions or insufficient increase in PSMA-VOL to qualify for PSMA-VOL_PD or PSMA-VOL_PD without appearance of new lesions |
| Response classifications | |
| PSA | Response: ≥50% decrease; progression: ≥25% increase |
| RECIP | Response: RECIP-PR; progression: RECIP-PD |
| PSA + RECIP | Response: PSA ≥ 50% decrease or RECIP-PR/RECIP-CR; progression: PSA ≥ 25% increase or RECIP-PD |