Demographics of 18F-THK5351 and 18F-SMBT-1 Selectivity Evaluations
| Demographic | 18F-THK5351 | 18F-SMBT-1 | ||
|---|---|---|---|---|
| CN | AD/MCI | CN | AD | |
| Total subjects (n) | 4 | 4 | 5 | 4 |
| Age (y) | 79.1 ± 6.7 | 74.9 ± 7.0 | 78.5 ± 6.0 | 76.7 ± 1.5 |
| Sex (n) | 3 M/1 F | 2 M/2 F | 2 M/3 F | 1 M/3 F |
| APOE4 | 25% | 50% | 60% | 67% |
| MMSE | 29.3 ± 0.5 | 25.7 ± 2.8* | 29.2 ± 0.8 | 22.8 ± 4.8* |
| CDR SoB | 0.0 ± 0.0 | 2.2 ± 0.4* | 0.0 ± 0.0 | 7.6 ± 2.1* |
| Aβ (centiloids) | 28.3 ± 54.7 | 82.7 ± 12.7 | 17.4 ± 10.2 | 127.6 ± 47.1 |
| Aβ+ | 25% | 100% | 60% | 100% |
↵* Statistically significant (P < 0.05).
MMSE = Mini Mental State Examination; CDR SoB = clinical dementia rating sum of boxes.
Continuous data are mean ± SD.