TABLE 2.

Tissue Classification Based on Radiomic Feature Classes and Signatures in 4-Tissue Model

Classification accuracy	Unharmonized		Harmonized		P
Classification accuracy	Median	Range	Median	Range	P
Gray-level histogram
Training	46.3	44.8–48.9	56.1	53.6–60.4	0.043
Validation	45.8	42.5–49.2	53.8	46.3–56.3	0.043
Gray-level cooccurrence matrix
Training	43.4	37.5–46.1	62.7	60.5–64.3	0.043
Validation	39.2	36.7–41.7	57.5	50.8–65.0	0.042
Gray-level run-length matrix
Training	46.3	43.4–47.1	63.0	57.3–64.5	0.042
Validation	41.7	40.4–47.9	59.2	52.5–61.7	0.043
Gray-level size-zone matrix
Training	43.4	41.4–43.8	86.0	83.0–87.5	0.043
Validation	39.6	36.3–42.9	82.5	68.8–85.0	0.043
Neighborhood gray-tone difference matrix
Training	42.1	39.6–45.0	62.7	60.0–64.3	0.043
Validation	42.5	36.7–46.7	61.3	57.1–65.8	0.043
Radiomic signature
Training	51.6	48.2–56.6	82.1	80.0–86.3	0.042
Validation	48.8	42.9–50.8	81.3	67.5–82.9	0.043