TABLE 2.

Parameter Estimates by Generalized Linear Mixed Model of Chromosome Breaks and Exchanges at 3 Months in HYPO and rhTSH Groups

Variable	Mean ± SE	95% CI	Exp (mean)	% chance	P
Chromosome breaks at 3 mo in HYPO patients*
Anti-ROMsS at 1 wk	−0.003 ± 0.001	−0.005 to −0.00005	1.00	−0.3	0.046
Exposure rate at 48 h	0.06 ± 0.02	0.01 to 0.10	1.06	6.2	0.016
Chromosome exchanges at 3 mo in HYPO patients^†
Anti-ROMsS at 1 wk	−0.009 ± 0.003	−0.02 to −0.002	0.99	−0.9	0.015
DNA-1	0.82 ± 0.34	0.10 to 1.54	2.28	127.5	0.027
Exposure rate at 48 h	0.06 ± 0.03	0.002 to 0.12	1.06	6.2	0.046
Chromosome breaks at 3 mo in rhTSH patients^‡
DNA-2	0.67 ± 0.25	0.03 to 1.31	1.95	95.4	0.04

* Covariate: age, sex, breaks at baseline, d-ROMs at baseline and 1 wk, anti-ROMsF at baseline and 1 wk, anti-ROMsS at baseline, DNA-1, DNA-2, and epi-GFR.
↵^†Covariate: age, sex, exchanges at baseline, d-ROMs at baseline and 1 wk, anti-ROMsF at baseline and 1 wk, anti-ROMsS at baseline, DNA-2, and epi-GFR.
↵^‡Covariate: age, sex, breaks at baseline, d-ROMs at baseline and 1 wk, anti-ROMsF at baseline and 1 wk, anti-ROMsS at baseline and 1 wk, DNA-1, dosimetry at 48 h, and epi-GFR.
Exp (mean) = exponential of the mean.