TABLE 2.

Univariable Cox Analyses for DMFS in Training Cohort^*

Parameter	HR^†	c-index	P
Clinical
Age, in y	1.020 (0.990–1.051)	0.540	0.197
Sex
Female	Reference
Male	1.861 (0.738–4.694)	0.532	0.188
Tobacco
No	Reference
Yes	2.112 (0.760–5.874)	0.533	0.152
Alcohol
No	Reference
Yes	1.111 (0.634–1.945)	0.517	0.714
PS
0–1	Reference
2	0.963 (0.133–6.988)	0.502	0.970
T classification
cT1–cT2	Reference
cT3–cT4	6.795 (1.981–23.334)	0.660	0.002
N classification
cN0	Reference
cN1	1.432 (0.530–3.874)	0.638	0.479
cN2	3.034 (1.518–6.088)	0.638	0.002
cN3	3.851 (1.072–13.827)	0.638	0.039
AJCC staging
I	Reference
II	1.389 (0.196–9.865)	0.595	0.742
III	3.116 (0.647–15.006)	0.595	0.156
IV	4.513 (1.089–18.708)	0.595	0.038
Tumor site
Oral cavity	Reference
Hypopharynx	1.946 (0.914–4.140)	0.578	0.084
Larynx	0.875 (0.374–2.049)	0.578	0.759
Oropharynx	1.094 (0.507–2.361)	0.578	0.818
Metabolic data
Tumor metabolic data
SUV_max	1.040 (1.010–1.072)	0.617	0.009
MTV at 15% of SUV_max	1.026 (1.016–1.036)	0.709	< 0.0001
MTV at SUV of 4.0	1.033 (1.020–1.046)	0.720	0.0000005
TLG at 21% of SUV_max	1.003 (1.002–1.005)	0.720	<0.0001
TLG at SUV of 4.0	1.003 (1.002–1.004)	0.714	0.0000008
Node metabolic data
MTV at 21% of SUV_max	1.011 (1.000–1.021)	0.694	0.04
MTV at SUV of 3.0	1.016 (1.007–1.026)	0.693	0.0002
TLG at 21% of SUV_max	1.002 (1.001–1.003)	0.698	0.004
TLG at SUV of 3.0	1.002 (1.001–1.026)	0.694	0.0006
Distance parameters
Maximal tumor–node distance	1.177 (1.092–1.269)	0.679	0.00002
dst_MTVweightedSumDistTN	1.002 (1.001–1.004)	0.696	0.00003
dst_MTVweightedMaxDistTN	1.003 (1.001–1.006)	0.68	0.01

↵* There were 51 patients with distant metastases.
↵^† Values in parentheses are 95% CIs.
dst_MTVweightedSumDistTN = sum of distances weighted by respective MTVs of metastases; dst_MTVweightedMaxDistTN = metastasis remoteness weighted by MTV of corresponding metastasis.