TABLE 1.

Univariable Cox Analyses for OS in Training Cohort^*

Parameter	HR^†	c-index	P
Clinical
Age, in y	1.011 (0.99–1.03)	0.509	0.28
Sex
Female	Reference
Male	1.51 (0.89–2.6)	0.53	0.12
Tobacco use
No	Reference
Yes	2.13 (1.11–4.1)	0.52	0.02
Alcohol use
No	Reference
Yes	1.34 (0.99–4.1)	0.55	0.1
PS
0–1	Reference
2	2.65 (1.07–6.5)	0.52	0.03
T classification
cT1–cT2	Reference
cT3–cT4	2.01 (1.4–2.9)	0.61	0.003
N classification
cN0	Reference
cN1	1.19 (0.69–2.05)	0.53	0.5
cN2	1.13 (0.75–1.7)	0.53	0.5
cN3	2.32 (0.83–6.45)	0.53	0.1
AJCC staging
I	Reference
II	2.17 (0.89–5.3)	0.575	0.09
III	3.11 (1.36–7.1)	0.575	0.007
IV	2.59 (1.24–5.4)	0.575	0.01
Tumor site
Oral cavity	Reference
Hypopharynx	1.81 (1.08–3.03)	0.55	0.02
Larynx	1.29 (0.78–2.15)	0.55	0.3
Oropharynx	1.26 (0.75–2.12)	0.55	0.4
Metabolic data^‡
Tumor metabolic data
SUV_max	1.004 (0.988–1.021)	0.54	0.58
MTV at 23% of SUV_max	1.02 (1.01–1.03)	0.64	<0.001
MTV at SUV of 2.5	1.01 (1.001–1.014)	0.61	0.038
TLG at 21% of SUV_max	1.001 (1.00–1.01)	0.61	0.04
TLG at SUV of 1.5	1.001 (1.000–1.002)	0.61	0.038
Node metabolic data
MTV at 21% of SUV_max	1.007 (1.001–1.013)	0.566	0.014
MTV at SUV of 3.0	1.010 (1.000–1.019)	0.563	0.014
TLG at 21% of SUV_max	1.001 (1.000–1.002)	0.564	0.02
TLG at SUV of 3.0	1.001 (1.000–1.002)	0.551	0.036
Maximal tumor–node distance	1.04 (0.99–1.1)	0.57	0.08
dst_TBarycenterN	1.08 (1.01–1.16)	0.58	0.02

↵* There were 116 deaths.
↵^† Values in parentheses are 95% CIs.
↵^‡ For PET parameters, data are given only for absolute and relative thresholds with highest c-index values.
PS = performance status; dst_TBarycenterN = distance between tumor and barycenter of all node metastases.