All Serious Adverse Events
| Subject | Event preferred term | Causality | Grade | Outcome |
|---|---|---|---|---|
| SAD1-01 | Disease progression | Not related | 5 | Fatal |
| SAD2-02 | Pain | Not related | 2 | Recovered |
| SAD2-02 | Cancer pain | Not related | 2 | Recovered |
| SAD2-02 | Dehydration | Not related | 2 | Recovered |
| SAD2-02 | Disease progression | Not related | 5 | Fatal |
| SAD2-02 | Low glomerular filtration rate | Not related | 3 | Recovered |
| MAD3-01 | Acute kidney injury | Unlikely | 2 | Recovered |
| MAD3-01 | Renal failure | Unlikely | 3 | Not recovered |
| MAD3-04 | Abdominal pain | Unlikely | 3 | Recovering |
| MAD4-01 | Worsening achalasia | Not related | 3 | Recovered |
| MAD4-03 | Dyspnea | Unlikely | 3 | Recovered |
| MAD4-03 | Fatigue | Unlikely | 2 | Resolved |
| MAD4-03 | Hypoglycemia | Unlikely | 2 | Resolved |
| MAD4-03 | Cerebrovascular accident | Unlikely | 2 | Resolved |
| MAD4-03 | Chronic kidney disease | Unlikely | 2 | Not recovered |