Characterization of Tumor-Responsive Liposomes Loaded with 225Ac-DOTA
| Size (nm) | ζ-potential (mV) | % loading | Specific activity* (MBq/μmol of lipid) | Retention kinetics (y = y∞ + a × e−bt) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| pH 7.4 | pH 6.5 | pH 6.0 | pH | y∞ (%) | a (%) | b (1/h) | t½ (h) | |||
| 118 ± 15 (polydispersity index, 0.099 ± 0.051) (n = 15) | −1.5 ± 1.4† (n = 15) | −0.8 ± 1.2‡ (n = 15) | −0.04 ± 1.1†‡ (n = 15) | 51.1 ± 8.6 (n = 15) | 0.5 ± 0.2 (n = 9) | 7.4 | 88.8 ± 0.7 | 10.9 ± 1.2 | 1.2 ± 0.3 | 0.6 ± 0.2 |
| 7.0 | 84.9 ± 1.3 | 13.8 ± 1.7 | 0.5 ± 0.1 | 1.4 ± 0.1 | ||||||
| 6.5 | 77.8 ± 1.2 | 21.2 ± 1.5 | 0.4 ± 0.1 | 1.7 ± 0.1 | ||||||
| 6.0 | 72.4 ± 0.7 | 27.8 ± 1.0 | 0.7 ± 0.1 | 1.0 ± 0.0 | ||||||