TABLE 1

Estimated Blood Pharmacokinetic Parameters

Parameter	⁸⁹Zr-IgG C4	⁸⁹Zr-IgG C4 (H310A/H435Q)	⁸⁹Zr-Fab C4
t_½β (h)	80.25	86.55	1.50
V_c (mL)	2.71	2.41	2.31
CL (mL⋅h⁻¹)	0.047	0.16	2.46
k₁₀ (h⁻¹)	0.017	0.066	1.06
k₁₂ (h⁻¹)	0.11	0.08	1.91
k₂₁ (h⁻¹)	0.12	0.02	1.92
AUC_plasma (%ID⋅h⋅mL⁻¹)	2,137	629	41

t_1/2β = biologic elimination half-life; V_c = volume of distribution of central compartment; CL = systemic clearance; k₁₀ = elimination rate constant from central compartment; k₁₂ = distribution rate constant from central to peripheral compartment; k₂₁ = distribution rate constant from peripheral to central compartment; AUC_plasma = plasmatic exposure.