Association Rate (ka), Dissociation Rate (kd), and Apparent Equilibrium Dissociation (KD) Constants for Interaction Between 125I-Trastuzumab and HER2-Expressing SKOV-3 Cells in Presence and Absence of ZHER2:342-SR-HP1 Determined Using Interaction Map Analysis of LigandTracer Sensorgrams
| Parameter | ka [(1/M × s) × 105] | kd [(1/s) × 10−6] | KD (pM) |
|---|---|---|---|
| 125I-trastuzumab only | 5.6 ± 0.0 | 2 ± 0.7 | 3.7 ± 1.2 |
| 125I-trastuzumab with ZHER2:342-SR-HP1 | 4.5 ± 0.2 | 1.9 ± 0.1 | 4.4 ± 0.7 |