177Lu-rhPSMA-7.3 (rh) | 177Lu-PSMA I&T (I&T) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Patient | Tumor no. | Tumor site | Tumor dose (mGy/MBq) | TI for kidneys | TI for bone marrow | Tumor dose (mGy/MBq) | TI for kidneys | TI for bone marrow | Ratio of tumor rh to tumor I&T | rTI for kidneys | rTI for bone marrow* |
1 | 1 | B | 3.00 | 1.91 | 3.63 | 1.31 | 2.07 | 3.45 | 2.30 | 0.92 | 1.05 |
2 | B | 1.58 | 1.01 | 1.91 | 0.73 | 1.16 | 1.94 | 2.16 | 0.87 | 0.99 | |
2 | 1 | B | 4.05 | 2.33 | 11.60 | 1.38 | 1.71 | 9.82 | 2.95 | 1.36 | 1.18 |
2 | B | 6.94 | 3.99 | 19.90 | 2.31 | 2.88 | 16.51 | 3.00 | 1.39 | 1.21 | |
3 | LN | 29.25 | 16.81 | 83.81 | 9.80 | 12.20 | 70.00 | 2.98 | 1.38 | 1.20 | |
4 | B | 2.81 | 1.62 | 8.05 | 0.88 | 1.09 | 6.27 | 3.20 | 1.48 | 1.28 | |
5 | B | 1.53 | 0.88 | 4.37 | 0.52 | 0.65 | 3.72 | 2.94 | 1.35 | 1.18 | |
3 | 1 | LN | 16.15 | 11.97 | 43.42 | 5.15 | 10.42 | 35.99 | 3.14 | 1.15 | 1.21 |
2 | LN | 14.00 | 10.37 | 37.63 | 5.93 | 12.01 | 41.49 | 2.36 | 0.86 | 0.91 | |
3 | B | 1.56 | 1.16 | 4.20 | 0.73 | 1.47 | 5.07 | 2.15 | 0.79 | 0.83 | |
4 | 1 | B | 2.21 | 1.24 | 8.24 | 0.92 | 0.97 | 8.45 | 2.40 | 1.28 | 0.98 |
2 | LN | 3.46 | 1.94 | 12.91 | 1.22 | 1.28 | 11.19 | 2.84 | 1.52 | 1.15 | |
5 | 1 | B | 6.88 | 3.23 | 3.55 | 2.79 | 2.96 | 3.26 | 2.47 | 1.09 | 1.09 |
2 | B | 6.67 | 3.13 | 3.44 | 3.00 | 3.18 | 3.51 | 2.22 | 0.99 | 0.98 | |
3 | B | 5.92 | 2.78 | 3.05 | 2.69 | 2.85 | 3.14 | 2.20 | 0.98 | 0.97 | |
4 | B | 9.49 | 4.46 | 4.89 | 4.37 | 4.63 | 5.11 | 2.17 | 0.96 | 0.96 | |
5 | B | 3.91 | 1.84 | 2.02 | 1.82 | 1.93 | 2.13 | 2.15 | 0.95 | 0.95 | |
6 | 1 | B | 0.66 | 0.50 | 3.38 | 0.38 | 0.66 | 4.00 | 1.72 | 0.75 | 0.85 |
2 | LN | 8.05 | 6.05 | 41.28 | 4.66 | 8.06 | 48.54 | 1.73 | 0.75 | 0.85 | |
3 | LN | 3.38 | 2.54 | 17.32 | 1.93 | 3.33 | 20.06 | 1.75 | 0.76 | 0.86 | |
4 | LN | 3.71 | 2.79 | 19.03 | 2.89 | 5.00 | 30.10 | 1.28 | 0.56 | 0.63 | |
Mean ± SD for all | 6.44 ± 6.44† | 3.93 ± 4.07‡ | 16.08 ± 19.79‡ | 2.64 ± 2.24 | 3.83 ± 3.58 | 15.89 ± 18.28 | 2.39 | 1.05 | 1.01 | ||
Mean ± SD for B | 4.09 ± 2.57§ | 2.15 ± 1.17‡ | 5.87 ± 4.68‡ | 1.70 ± 1.13 | 2.02 ± 1.11 | 5.46 ± 3.76 | 2.43 | 1.08 | 1.03 | ||
Mean ± SD for LN | 11.14 ± 8.83‡ | 7.50 ± 5.27‡ | 36.49 ± 22.49‡ | 4.51 ± 2.69 | 7.47 ± 4.03 | 36.77 ± 17.90 | 2.30 | 1.00 | 0.97 |