Demographic, Clinical, SPECT, and Surgical Data
| Data | Responder* | Nonresponder* | P† |
|---|---|---|---|
| Number of patients | 18 | 18 | |
| Sex (% females) | 44 | 44 | 1.00 |
| Age at ictal SPECT (y) | 43 [28–49] | 34 [24–48] | 0.24 |
| Age at first seizure (y) | 14 [6–23] | 12 [4–23] | 0.61 |
| Duration of disease at SPECT (y) | 22 [15–34] | 21 [11–33] | 0.56 |
| Mean seizure frequency in last 12 mo before ictal SPECT (seizures/mo) | 5 [3–21] (n = 15) | 14 [5–23] (n = 16) | 0.36 |
| With impairment of awareness in most seizures during the last 12 mo (%) | 77 (n = 13) | 79 (n = 14) | 1.00 |
| Lateralization of seizure semiology: ipsilateral to resection/contralateral/both/no (%) | 93/7/0/0 (n = 14) | 90/0/0/10 (n = 10) | 0.35 |
| Lateralization of MRI: ipsilateral to resection/contralateral/both/no (%) | 94/0/0/6 (n = 18) | 82/0/6/12 (n = 17) | 0.45 |
| Lateralization of ictal EEG before ictal SPECT: ipsilateral to resection/contralateral/both/no (%) | 88/6/6/0 (n = 16) | 88/0/0/12 (n = 17) | 0.26 |
| Lateralization of interictal EEG before ictal SPECT: ipsilateral to resection/contralateral/both/no (%) | 83/6/11/0 | 67/0/22/11 | 0.26 |
| Tracer of ictal SPECT (% 99mTc-ECD) | 94 | 56 | 0.02 |
| Tracer activity administered for ictal SPECT (MBq) | 524 [479–639] | 578 [501–632] | 0.34 |
| Latency of tracer injection to seizure start in EEG (s) | 30 [25–35] | 40 [30–49] | 0.02 |
| Seizure duration after injection according to EEG (s) | 74 [43–147] | 57 [31–106] | 0.28 |
| Delay of surgery after ictal SPECT (mo) | 10 [4–27] | 6 [2–24] | 0.70 |
| Side of TLE surgery (% right) | 67 | 67 | 1.00 |
| Neuropathology of surgical specimen: normal/sclerosis/mass lesion/focal cortical dysplasia | 13/75/6/6 (n = 16) | 17/67/17/0 (n = 12) | 0.66 |
* Continuous variables are given as median, with interquartile range in brackets. If a variable was not available in all patients, the number of patients for that variable is given in parentheses.
↵†P values are not corrected for multiple testing.