Response to Therapy in DTC Patients: Dynamic Risk Stratification Criteria (Modified from [6])
| Excellent response: No clinical, biochemical, or structural evidence of disease: negative imaging and either suppressed Tg <0.2 ng/mL or stimulated Tg <1 ng/mL |
| Biochemical incomplete response: Abnormal Tg (i.e., suppressed Tg >1 ng/mL or stimulated Tg >10 ng/mL) or rising anti-Tg antibody levels in the absence of localizable disease (i.e., negative imaging) |
| Structural incomplete response: Persistent or newly identified locoregional or distant metastases (any Tg value) |
| Indeterminate response: Nonspecific biochemical (i.e., suppressed Tg 0.2–1 ng/mL or stimulated Tg 1–10 ng/mL or stable/declining anti-Tg antibody levels) or structural findings that cannot be confidently classified as either benign or malignant |
Tg = thyroglobulin.