Unmet Diagnostic Needs in Cardiovascular Medicine
| Clinical field | Unmet need |
|---|---|
| Heart failure and cardiomyopathies | Heart failure with preserved ejection fraction: phenotypic characterization, therapeutic development |
| Heart failure with reduced ejection fraction: prognostication, precision approaches to therapy | |
| Post–myocardial infarction remodeling: prognostication | |
| Immunotherapy/chemotherapy-related cardiotoxicity: prediction, early recognition, prognostication, and assessment of treatment response | |
| Cardiac amyloidosis: single-scan diagnosis and typing (light-chain amyloidosis vs. transthyretin amyloidosis) | |
| Cardiac sarcoidosis: reduce dependence on dietary preparation, differentiate from other types of myocarditis/nonspecific uptake | |
| Genetic cardiomyopathies: risk stratification in asymptomatic or phenotype-negative carriers and those carrying variants of unknown significance | |
| Cardiac fibrosis: reproducible quantification, distinguish between active and stable disease | |
| Left ventricular assist devices: prediction of left ventricular myocardial recovery | |
| New medical therapies (e.g., angiotensin receptor neprilysin inhibitors, sodium glucose cotransporter 2 inhibitors): determination of mechanism of action, track therapeutic response | |
| Arrhythmias | Sudden cardiac death: risk stratification, prediction of implantable cardiac defibrillator benefit |
| Genetic arrhythmia syndromes: risk stratification in asymptomatic or phenotype-negative carriers and those carrying variants of unknown significance | |
| Atrial fibrillation: patient selection for ablation/cardioversion/antiarrhythmic drugs | |
| Valvular disease | Valvular regurgitation/stenosis: determination of risk for progression, prediction of optimal timing of interventions, selection for medical therapy, tracking of therapeutic response |
| Endocarditis or device infections: detection | |
| Vascular disease | Atheroma: risk stratification |
| Aortic aneurysm: risk stratification, prediction of endoleak | |
| Thrombosis or embolization: whole-body detection, determination of chronicity | |
| Perfusion: high-spatial-resolution imaging with absolute blood flow quantification, hybrid perfusion/angiographic imaging | |
| Peripheral artery disease: risk stratification, prediction of interventional benefit |