TABLE 2

Multivariable Analyses of Clinical (Age, Sex, ECOG PS, KRAS, BMI) and PET-Based Variables (Baseline WB-MATV and Early mR According to Different Methods) for OS and PFS in Development and Validation Sets

Development setValidation set
OSPFSOSPFS
VariableHR (95% CI)PHR (95% CI)PHR (95% CI)PHR (95% CI)P
Baseline WB-MATV (adjusted for clinical factors)2.56 (1.90–3.44)<0.0012.00 (1.51–2.66)<0.0011.87 (1.17–2.97)0.0051.94 (1.27–2.97)0.002
ECOG PS1.47 (1.12–1.94)0.0062.01 (1.08–3.74)0.03
BMI1.62 (1.22–2.16)0.001
Early mR (adjusted for clinical factors)
 PERCIST–30%1.48 (1.09–2.02)0.01
 PERCIST–15%1.60 (1.17–2.18)0.0031.84 (1.35–2.51)<0.0011.50 (0.90–2.50)0.121.68 (1.02–2.79)0.04
 EORTC1.52 (1.08–2.13)0.021.52 (1.09–2.11)0.011.43 (0.83–2.47)0.201.49 (0.88–2.50)0.14
 CONSIST1.70 (1.26–2.29)<0.0011.71 (1.27–2.28) <0.0011.99 (1.22–3.26)0.0061.98 (1.24–3.15)0.004
 ECOG PS1.50 (1.11–2.01)0.008
 BMI1.89 (1.38–2.58)<0.001
Early mR (adjusted for clinical factors and baseline WB-MATV)
 PERCIST–30%1.36 (1.00–1.85)0.05
 PERCIST–15%1.56 (1.14–2.12)0.0051.91 (1.39–2.61) <0.0011.41 (0.84–2.38)0.191.49 (0.89–2.48)0.13
 EORTC1.45 (1.03–2.03)0.031.54 (1.10–2.15)0.011.37 (0.79–2.37)0.261.33 (0.79–2.24)0.29
 CONSIST1.55 (1.15–2.11)0.0051.64 (1.23–2.20)<0.0011.79 (1.08–2.95)0.021.69 (1.04–2.73)0.03
 ECOG PS1.38 (1.02–1.86)0.035
 BMI1.71 (1.25–2.34)0.001
 Baseline WB-MATV2.22 (1.61–3.06)<0.0011.69 (1.24–2.30)0.0011.82 (1.12–2.97)0.0161.79 (1.14–2.80)0.01
  • BMI = body mass index.