Patient and Study Characteristics
| Characteristic | All | Diabetic | Nondiabetic |
|---|---|---|---|
| Patient characteristics | |||
| n | 59 | 42 | 17 |
| Age (y) | 62 ± 10 | 63 ± 11 | 62 ± 11 |
| Sex | |||
| Male | 48 | 32 | 16 |
| Female | 11 | 10 | 1 |
| Ejection fraction (%) | 29 ± 10 | 30 ± 9 | 27 ± 9 |
| Prior CABG | 4 | 3 | 1 |
| Prior PTCA | 5 | 3 | 2 |
| Prior myocardial infarction | 43 (73%) | 27 (64%) | 16 (94%) |
| Hypertension | 57 (96%) | 25 (60%) | 16 (94%) |
| Smoking | 39 (66%) | 28 (67%) | 11 (65%) |
| Dyslipidemia | 53 (90%) | 38 (90%) | 15 (88%) |
| Diabetes mellitus | 42 (71%) | 42 (100%) | 0 (0%) |
| Study characteristics with intravenous glucose load | |||
| Glucose at baseline (mg/dL) | 121 ± 32 (70–214) | 131 ± 33 (70–214) | 97 ± 11* (83–122) |
| Glucose peak after challenge (mg/dL) | 184 ± 31 (124–304) | 188 ± 33 (126–304) | 175 ± 24 (124–203) |
| Glucose before imaging (mg/dL) | 101 ± 25 (62–166) | 108 ± 24 (63–166) | 87 ± 20* (62–146) |
| Insulin (U) | 6.3 ± 2.2 (2–11) | 6.8 ± 2.3 (2–11) | 4.9 ± 1.3* (3–8) |
| MPP (min) | 51 ± 15 (25–89) | 51 ± 16 (25–85) | 50 ± 14 (30–89) |
| 18F-FDG uptake period (min) | 82 ± 19 (52–122) | 86 ± 19 (52–122) | 74 ± 17* (54–115) |
| Preparation period (min) | 133 ± 26 (83/190) | 137 ± 25 (83–190) | 124 ± 25 (92–184) |
| Study characteristics with oral glucose load | |||
| Glucose at baseline (mg/dL) | 99 ± 9 (84–112) | 105 ± 5 (101–112) | 91 ± 7* (84–99) |
| Glucose peak after challenge (mg/dL) | 158 ± 26 (123–187) | 171 ± 11 (164–187) | 146 ± 32* (116–185) |
| Glucose before imaging (mg/dL) | 105 ± 23 (76–144) | 101 ± 23 (76–129) | 108 ± 28 (82–144) |
| Insulin U) | 2.0 ± 1.69 (0–5) | 3.0 ± 1.63 (1–5) | 1.0 ± 1.16* (0–2) |
| MPP (min) | 132 ± 29 (90–180) | 141 ± 31 (110–180) | 122 ± 28* (90–158) |
| 18F-FDG uptake period (min) | 72 ± 15 (57–98) | 64 ± 11 (57–80) | 80 ± 17*(62–98) |
| Preparation period (min) | 203 ± 25 (167–237) | 205 ± 33 (167–237) | 201 ± 19 (187–228) |
*P ≤ 0.05 vs. diabetic group.
CABG = coronary artery bypass surgery; PTCA = percutaneous transluminal coronary angioplasty; 18F-FDG uptake period = time from 18F-FDG injection to start of imaging; preparation period = time from start of MPP to start of imaging.
Qualitative data are number and percentage; continuous data are mean and range.