Patient no. | Initial diagnosis | First PTRT cycle | FAP PTRT cycles (n) | Response* at 6–8 wk after first cycle | Response* at 6–8 wk after third cycle, if applicable | Time to progression since initial PTRT (wk) | Death | Cause of death | Survival since initial FAP PTRT (mo) |
---|---|---|---|---|---|---|---|---|---|
1 | 09/2019 | 10/2019 | 2 | PD | 8 | 03/2020 | PD | 5 | |
2 | 03/2019 | 10/2019 | 2 | PD | 8 | 06/2020 | PD | 8 | |
3 | 09/2019 | 10/2019 | 2 | PD | 8 | 12/2019 | Suicide | 2 | |
4 | 02/2018 | 10/2019 | 2 | PD | 8 | 02/2020 | PD | 4 | |
5 | 01/2019 | 12/2019 | 2 | PD† | 8 | 04/2020 | PD | 4 | |
6 | 07/2015 | 10/2019 | 2 | PD | 8 | Patient alive (05/2021) | |||
7 | 09/2004 | 10/2019 | 2 | PD | 8 | 04/2020 | PD | 6 | |
8 | 07/2013 | 10/2019 | 3 | SD | PD | 24 | Patient alive (05/2021) | ||
9 | 05/2008 | 10/2019 | 2 | SD | 20 | Patient alive (05/2021) | |||
10 | 03/2015 | 10/2019 | 2 | PD | 8 | 01/2020 | PD | 3 | |
11 | 02/2009 | 10/2019 | 1 | PD | 6 | 01/2020 | Bronchopneumonia | 3 |
*Response was evaluated by RECIST 1.1, on 68Ga-FAP-2286 PET/CT (except in patient 5) and tumor marker evaluation after first (in all) and third (in patient 8) PTRT cycles.
↵†Response was evaluated on RECIST 1.1 and tumor marker evaluation.
FAP = fibroblast activation protein; PTRT = peptide-targeted radionuclide therapy; PD = progressive disease.