Patients with Suspected Insulinoma Who Underwent Both Carbidopa-Assisted 18F-DOPA and 68Ga-DOTATOC PET/CT
| Patient no. | Age (y) | Sex | 24-h fast test | Medical treatment | CT/MRI | EUS | Early/delayed 18F-DOPA/SSTR PET/CT | Final diagnosis | Gold standard |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 62 | F | Positive | Diazoxide | +/+, head | +, head | +/+/+, head | Insulinoma, 10-mm, grade 1, Ki-67: 2% | Pathology (surgery) |
| 2 | 31 | F | Doubtful | Diazoxide | −/− | ?, body | −/−/− | Insulinoma excluded | Consensus |
| 3 | 16 | F | Positive | Diazoxide | −/− | — | −/−/− | Insulinoma excluded | Consensus |
| 4 | 70 | M | Positive | Diazoxide | +/+, tail | +/+/+, tail | Nonfunctioning pNET, 66-mm, grade 3, Ki-67: 25% | Pathology (surgery) | |
| 5 | 19 | F | Positive | −/− | −/−/− | Insulinoma excluded | Consensus | ||
| 6 | 62 | F | Positive | +/NA, body | +, body | −/−/+, body | Insulinoma, 17-mm | Pathology (FNAB) | |
| 7 | 71 | F | Doubtful | −/NA | − | +/+/+, head | Insulinoma, 18-mm, grade 1, Ki-67: 1% | Pathology (surgery) | |
| 8 | 77 | F | Doubtful | −/− | ?, tail | −/−/− | Insulinoma excluded | Consensus | |
| 9 | 65 | M | Positive | −/− | +, body | −/−/− | MiNEN, 10-mm, grade 1 (IHC: 15% insulin-positive, 90% SST-positive) | Pathology (surgery) | |
| 10 | 48 | F | Positive | +/+, tail | +/+/+, tail | Insulinoma, 17-mm, grade 1, Ki-67: 1% | Pathology (surgery) | ||
| 11 | 78 | F | Positive | Diazoxide | +/NA, tail | −/−/− | Insulinoma, 12-mm, grade 1, Ki-67: 2% | Pathology (surgery) | |
| 12 | 64 | F | Positive | −/− | −/−/− | Insulinoma excluded | Consensus | ||
| 13 | 27 | F | Doubtful | +/+, head | +/−/+, head | Insulinoma, 10-mm (MRI) | Consensus | ||
| 14 | 64 | M | Doubtful | −/− | −/−/− | Insulinoma excluded | Consensus | ||
| 15 | 78 | F | Doubtful | −/NA | −/−/− | Insulinoma excluded | Consensus | ||
| 16 | 29 | F | Positive | −/+, tail | +/+/−, tail | Insulinoma, 12-mm, grade 1, Ki-67: 1% | Pathology (surgery) | ||
| 17 | 67 | F | Positive | Diazoxide | −/− | − | −/−/− | Insulinoma (occult) | Consensus |
| 18 | 64 | F | Doubtful | −/+, body | +, body | −/−/− | Nonfunctioning pNET, 5-mm, grade 1, Ki-67: 1% | Pathology (FNAB) | |
| 19 | 72 | M | Positive | Diazoxide | +/NA, head | + | −/−/+, head | Insulinoma, 10-mm | Pathology (FNAB) |
| 20 | 93 | M | Positive | Diazoxide | +/NA, tail | − | −/−/+, tail | Insulinoma, 13-mm | Consensus |
| 21 | 52 | M | Positive | NA/+, head | +, head | −/−/− | Insulinoma, 22-mm | Pathology (FNAB) |
EUS = endoscopic ultrasound; + = positive result; − = negative result; ? = doubtful result; pNET = pancreatic neuroendocrine tumor; NA = not available; FNAB = fine-needle aspiration biopsy; MiNEN = mixed neuroendocrine–nonneuroendocrine neoplasm; IHC = immunohistochemistry.