Relative Difference in Cumulative AD for 65 Individual Tumors over 2–9 Cycles When Introducing Simplifications to Dosimetry Protocol, When Using LMM to Interpolate Missing Cycle Data, and When Using Complete LMM
| Alternative | Description | Mean (%) | Limits of agreement (%) |
|---|---|---|---|
| A | Simplification using constant AD/cycle, from first cycle | 15 | 55 |
| B | Simplification using constant effective half-time, from first cycle | 0.43 | 13 |
| C | Simplification using constant effective half-time, global means (G1, 103 h; G2, 81 h) | 0.01 | 31 |
| D | Interpolation, LMM intercept patient- and tumor-effective half-time (Eq. 2) | 1.6 | 7.9 |
| E | Complete LMM for effective half-time or AD (Eq. 1) | −1.0 | 3.3 |
Relative difference is calculated as (AD simplified protocol/AD complete dosimetry – 1). Limits of agreement are derived from Bland–Altman plots (Supplemental Fig. A4).