Description of Simulations
| Site A | Site B | Site C | |||
|---|---|---|---|---|---|
| Experiment | Limited stage | Advanced stage | Limited stage | Advanced stage | Limited stage |
| Experiment 1 (virtual site), reference site = A | N = 1,000, μ = 8, SD = 3 | ø | N = 1,000, μ = 12, SD = 4 | ø | N = 1,000, μ = 14, SD = 5 |
| Experiment 2, reference site = A | N = 1,000, μ = 8, SD = 3 | N = 1,000, μ = 10, SD = 3 | N = 1,000, μ = 12, SD = 4 | N = 1,000, μ = 14, SD = 4 | ø |
| Experiment 3, reference site = A, without and with covariate (=stage) | N = 1,000, μ = 8, SD = 3 | N = 1,000, μ = 10, SD = 3 | N = 1,000, μ = 12, SD = 4 | ø | ø |
| Experiment 4, reference site = A, without and with covariate (=stage) | N = 1,000, μ = 8, SD = 3 | N = 1,000, μ = 10, SD = 3 | N = 200, μ = 12, SD = 4 | N = 1,800, μ = 14, SD = 4 | ø |
| Experiment 5, reference site = A, without and with covariate (=stage) | N = 1,000, μ = 8, SD = 3 | N = 1,000, μ = 10, SD = 3 | N = 1,000, μ = 12, SD = 4 | N = 1,000, μ = 12, SD = 4 | ø |
| Experiment 6, reference site = A, without and with covariate (=stage) | N = 1,000, μ = 8, SD = 3 | N = 1,000, μ = 10, SD = 3 | N = 1,000, μ = 12, SD = 4 | N = 1,000, μ = 20, SD = 4 | ø |
N = number of simulated samples; μ = mean of gaussian distribution; ø = no simulation for this category.