TABLE 2

Radiolabeling Yields for ¹²⁵I/²¹¹At-3-Lu

Radionuclide	Starting radioactivity	Age of ²¹¹At	Method of preparation	n	% yield^*
¹²⁵I	0.170–0.266 GBq (4.6–7.2 mCi)	Not applicable	A	2	46.5 ± 7.7
¹²⁵I	0.054–0.518 GBq (1.47–14 mCi)	Not applicable	B	4	62.8 ± 9.0
²¹¹At	0.16–0.31 GBq (4.4–8.5 mCi)	Fresh	A	3	6.3 ± 1.8
²¹¹At	0.126- 0.34 GBq (3.4–9.2 mCi)	Fresh	B	2	17.8 ± 8.2
²¹¹At	0.44–0.66 GBq (12.0–17.0 mCi)	≥9 h	A	2	8.6 ± 3.6
²¹¹At	0.115–0.877 GBq (3.1–23.7 mCi)	≥9 h	B	4	13.6 ± 8.4

↵* After preparative high-performance liquid chromatography purification.
A = separate preparative high-performance liquid chromatography purification of ¹²⁵I/²¹¹At-3 and ¹²⁵I/²¹¹At-3-Lu. B = preparative high-performance liquid chromatography purification of ¹²⁵I/²¹¹At-3-Lu only.