Characteristic | Total cohort | Confined | mETE | P* (univariable analysis) |
---|---|---|---|---|
Number of patients | 721 | 644 (89.3) | 77 (10.7) | |
Number of metastasized lymph nodes | 0 (IQR–0,0) | 0 (IQR–0,0) | 0 (IQR–0,1) | <0.001 |
Nodal stage given by histopathologic examination of surgical specimen | <0.001 | |||
pN0 | 137 (19.0) | 120 (18.6) | 17 (22.1) | |
pN1a | 57 (7.9) | 39 (6.1) | 18 (23.4) | |
pN1b | 22 (3.1) | 13 (2.0) | 9 (11.7) | |
pNx | 505 (70.0) | 472 (73.3) | 33 (42.9) | |
Five-year cumulative incidence of LNM relapse (%) | 2.54 (95% CI, 1.57–3.91) | 1.25 (95% CI, 0.59–2.37) | 13.12 (95% CI, 6.69–21.77) | <0.001 |
Five-year cumulative incidence distant metastasis relapse‡ (%) | 1.83 (95% CI, 1.03–3.03) | 1.11 (95% CI, 0.50–2.19) | 7.79 (95% CI, 3.16–15.19) | <0.001 |
Tumor size (mm) | 5.00 (IQR, 3.00–8.00) | 5.00 (IQR, 3.00–8.00) | 8.00 (IQR, 6.00–10.00) | <0.001 |
Multifocal disease | 135 (18.7) | 118 (18.3) | 17 (22.1) | 0.520 |
*Determined with Fisher exact test for categoric variables and Wilcoxon test for continuous variables.
†Assessed in subset of patients without distant metastases at thyroidectomy (n = 719).
IQR = interquartile range.
Qualitative data are number followed by percentage, except for 5-y cumulative incidence of LNM relapse; continuous data are mean ± SD, or median followed by 95% CI or IQR.